Given the Cavs position, any NBA news is big right now. So the Spurs losing Manu Ginobili for the playoffs is very big. Gregg Popovich always, always does his best to make sure his players are fresh and rested for the playoffs, so this is a serious blow.
Said one scout on NBA.com:
"I don't think you can ever really challenge the heart that this team has had and perseverance over the years so, if anyone's faced adversity and knows what it takes to win, it's them. That alone could get them through [past the first round]. But, you got a lot of x-factors. You got a very stacked Western Conference. You got a Trail Blazer team that, if they are to advance in the playoffs, would be one of the youngest teams in the last 20 years to do so and know no fear. It's not a time to go in less than 100 percent for a veteran Spurs club."
Charley Rosen of Foxsports.com is more succinct: "If the aging San Antonio Spurs were heading downhill anyway, the season-ending injury to Manu Ginobili pushes them over the edge and into free fall."